NCAPG2 peptides: A novel cancer therapeutic agent
Date Posted: 17/10/2018
Successful cell division depends on the proper attachment of microtubules to the kinetochore of each chromosome. NCAPG2, a component of condensin II Complex, aids in this process by recruiting protein polo-like kinase 1 (or PLK1) to the kinetochore. Proper localization of PLK1 to the kinetochore prevents cell division from proceeding until each kinetochore is properly attached to a microtubule. Thus, in the absence of NCAPG2-PLK1 binding, abnormal cell division may occur before all chromosomes are properly attached, resulting in chromosomal defects that can halt cell division altogether. For more information, please click here.