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Last Updated: 13/Sep/2019 The present invention relates to an apparatus for monitoring pulmonary edema, which can continuously monitor lung condition during the treatment in patients with severe stage diseases or patients in shock.
Last Updated: 13/Sep/2019 The present invention relates to a composition comprising melittin for suppressing tumor progression through inhibition of angiogenesis by selectively inhibiting M2-like tumor associated macrophages (TAM) without inhibiting M1 macrophage function.
Last Updated: 13/Sep/2019 The present invention relates to a composition comprising a phosphodiesterase (PDE) inhibitor for preventing or treating neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Lou Gehrig’s disease.
Last Updated: 13/Sep/2019 The invention relates to a peptide that inhibits the stemness of embryonal carcinoma (EC) by post-translational modification such as phosphorylation of OCT4.
Last Updated: 13/Sep/2019 The present invention relates to a novel bio-photonic device that can simultaneously diagnosis and treat pressure ulcers.
Last Updated: 13/Sep/2019 The present invention relates to hepatocellular carcinoma (HCC) specific biomarkers. More particularly, it includes biomarkers to detect and diagnose HCC by using genes whose expression levels change specific to HCC.
Last Updated: 13/Sep/2019 The present invention relates to a method to inhibit the survival and proliferation of Mycobacterium tuberculosis (Mtb) by regulating a polarity control of macrophages. More particularly, it includes a composition for inhibiting the survival and proliferation of Mtb by inducing polarization of macrophages through li...
Last Updated: 13/Sep/2019 The present invention relates to composition for preventing or treating pulmonary fibrosis disease comprising M-CSF inhibitor and G-CSF inhibitor as an active ingredient. More particularly, it includes composition for preventing or treating pulmonary fibrosis disease by decreasing factors related to myofibroblast diff...
Last Updated: 13/Sep/2019 The present invention relates to protein tyrosine phosphatase conjugated with a novel transdermal delivery peptide, astrotactin 1–derived peptide recombinant protein tyrosine phosphatase (AP-rPTP). More particularly, it includes its use for treating inflammatory skin diseases using the above fusion peptide.
Last Updated: 13/Sep/2019 The present invention relates to a cell-permeable peptide having a function of blood–brain barrier (BBB) or blood-spinal cord barrier (BSCB)-penetration, dNP2-congugated cytoplasmic domain of cytotoxic T-lymphocyte antigen 4 (ctCTLA-4) protein. More particularly, it includes its use for treating central nervous...
Last Updated: 28/Jun/2019 The present invention relates to synthetic peptide containing the amino-acid sequence derived from apoptosis inhibitor 5 (API5) and fibroblast growth factor 2 (FGF2). More particularly, it includes a method for screening for material to reduce anticancer drug resistance using the above synthetic peptide.
Last Updated: 28/Jun/2019 The present invention relates to a device to stabilize pressure changes of gases injected to secure space for surgery.
Last Updated: 28/Jun/2019 The present invention relates to a technology for a pharmaceutical composition containing streptonigrin and other anticancer drugs to prevent or treat cancer. More particularly, the anticancer drugs include gemcitabine, bortezomib, rapamycin or cisplatin.
Last Updated: 28/Jun/2019 The present invention relates to a technology for using a malate-aspartate shuttle (MAS) inhibitor as an agent for treating cancer. More particularly, provided is a pharmaceutical composition for preventing and treating cancer, containing, as an active ingredient, phenyl succinic acid, methyl malonic acid, N-(1-pyren...
Last Updated: 4/Jun/2019 The present invention relates to the nanocomplex of poly(ethylene glycol) and catechin as an active ingredient for preventing or treating dry eye disease .
Last Updated: 2/Jun/2019 Pharmaceutical composition for treating xerophthalmia, comprising a compound of the present invention one-off compression bandage (hands free system)
Last Updated: 2/Jun/2019 Our small molecule called MSL-5 can treat an Alzheimer’s disease animal model by enhancing autophagic degradation and Hsp70-dependent proteasomal degradation of Aβ/Tau proteins.
Last Updated: 27/May/2019 The present invention relates to pulmonary surfactant based anticancer drugs which effectively target lung cancer cells, particularly adenocarcinomas derived from alveolar type II cells.
Last Updated: 27/May/2019 The present invention relates to a composition for detecting dsRNA comprising merocyanine, salts thereof, or isomer thereof and method for providing information on diagnosing cancer using analyzing dsRNA expression.
Last Updated: 27/May/2019 The present invention relates to a composition containing Rho-associated protein kinase inhibitors for enhancing immune response and a method thereof.
Last Updated: 21/May/2019 The present invention relates to discovery of novel tau-targeted therapeutic drug candidates for the treatment of Alzheimer’s disease (AD).
Last Updated: 21/May/2019 The present invention relates to a pharmaceutical composition for the prevention or treatment of lung fibrosis , comprising stearic acid or its pharmaceutically acceptable salts and antifibrotic agents thereof as an active ingredient.
Last Updated: 12/May/2019 The present invention relates to a rapid and background-free lateral flow immunoassay (LFA) platform that utilizes near-infrared (NIR)-to-NIR upconversion nanoparticles (UCNPs)
Last Updated: 12/May/2019 The present invention relates to development of novel vinylsulfone compounds as Nrf2 activator for treatment of Parkinson’s disease (PD).
Last Updated: 12/May/2019 The present invention relates to a method of manufacturing complex nanocage loaded with anthracycline anticancer drug in nanocage produced by the fusion protein of SiRPα and ferritin heavy chain protein.
Last Updated: 25/Mar/2019 The present invention relates to a nucleic acid extraction method using a solid subject by forming a complex of a nucleic acid sample and an imidoesters compound in the subject.
Last Updated: 18/Oct/2018 This invention provides a pharmaceutical composition for prevention and treatment of the Middle East Respiratory Syndrome (MERS) and an anti-adsorption agent for the Middle East Respiratory Syndrome coronavirus (MERS-CoV)
Last Updated: 18/Oct/2018 Biomarkers for predicting response to anti-TNF agents Compositions for predicting response to anti-TNF agents Kits for predicting response to anti-TNF agents
Last Updated: 18/Oct/2018 The present invention relates to a composition for diagnosing neurofibromatosis comprising a genomic DNA-based long PCR primer set and a method for diagnosing neurofibromatosis using the same.
Last Updated: 16/Oct/2018 Researher has explored the relationship between PD-1’s receptor, PD-L1 expression and MSI-H gastric carcinomas, to determine if the former could be developed as a potential predictive biomarker in determining the prognosis of patients with this tumor subtype.
Last Updated: 14/Oct/2018 The present invention relates to a patient-specific immunocompetent cell sheet construct consisting of stem cell spheroids through three-dimensional culture technique and the patient’s own histiocytic cells
Last Updated: 14/Oct/2018 The present invention relates to a screening method for inhibiting colorectal cancer by regulating HSPA1L-mediated GP78 and HIF-1α, thereby controlling PrP C levels in colorectal cancer
Last Updated: 14/Oct/2018 The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis, wherein the fluorescent dye comprises a covalently labelled antibody and is structured to be quenched by interaction with a residue in the antibody, selected from the group consisting ...
Last Updated: 14/Oct/2018 On-site pretreatment device capable of pretreatment of high-risk infectious samples without BSL 2 to 4 levels of separate experimental environment cannot be installed POCT and professional experimenter All in One sealed pretreatment device (sample collection + chemical dissolution + mechanical dissolution)
Last Updated: 14/Oct/2018 This invention is an operation method of ocular tumor treatment system with improved safety and an ocular tumor treatment system. An object of the present invention, during treatment of tumors of the eyeball using a proton beam, in the case where the motion range of the eye group more than the set error range, to blo...
Last Updated: 14/Oct/2018 Consisting of a polysaccharide, a derivative thereof(dextrin, oligosaccharide, hyaluronic acid) and a polyethylene glycol Biocompatible nanoparticle formed by only inter-molecular cross-linking or intra-molecular cross-linking
Last Updated: 11/Oct/2018 SphK1 levels could be increased, in both disease types, using either molecular players affecting its expression or via genetic modifications. This increase in turn was found to reverse several of the disease hallmarks seen in the SphK1-deficient conditions.
Last Updated: 11/Oct/2018 The researchers achieved a major breakthrough by developing a method for forming CRISPR nanocomplexes consisting of a polymer-derivatized Cas9 protein, and guide RNA that target antibiotic resistance genes.
Last Updated: 11/Oct/2018 The researchers demonstrated that expression of these optimized RNA molecules induced immunogenic cell death in cancer cells, but not in non-cancer cells
Last Updated: 11/Oct/2018 BEAR presents several advantages over conventional VS methods, in that it depends on the bioactivity data rather than structural information, it facilitates scaffold hopping, and can easily be scaled to screen for thousands of targets.
Last Updated: 11/Oct/2018 Development of PPI-based anticancer drug using NCAPG2 which is newly identified PLK1 binding protein and the PBD binding structure of PLK1
Last Updated: 8/Oct/2018 The present invention relates to a method for constructing metal coordinated complexes with pegylated bilirubin by simple conjugation making amide bond in carboxylate using hydrophilic cloaking agent, PEG (poly ethyleneglycol), and its diverse applications.
Last Updated: 8/Oct/2018 YE-06 presents as a novel AMPK activator, which could be a promising therapeutic agent for the prevention and treatment of a wide range of age-related metabolic diseases, including diabetes, obesity, and dementia.
Last Updated: 8/Oct/2018 The researchers found that administration of BA in mice resulted in decreasing their body weight and fat mass, which was attributed to an increase in energy expenditure when compared to control mice.
Last Updated: 8/Oct/2018 The expression of pyruvate dehydrogenase kinase 2/4 was significantly increased in hindpaw of rats that induced chronic inflammatory pain through complete Freund's adjuvant(CFA) injection and it is associated with painful behavior, hindpaw edema and inflammatory response.
Last Updated: 8/Oct/2018 This cell culture techniques promise to revolutionize the field of assisted reproduction and embryo culture, setting new benchmarks for improving successful oocyte preservation and embryo development and selection, and ultimately enhancing the success of assisted reproductive technologies.
Last Updated: 8/Oct/2018 The present invention provides pharmaceutical compositions comprising sulfonamide compounds such as sulfisoxazole or sulfadoxine for inhibition of cancer cell proliferation, invasion and metastasis.
Last Updated: 7/Oct/2018 The present invention relates to a method for producing a site-specifically and authentically PTM-modified target protein via new carbon-carbon bond formation
Last Updated: 7/Oct/2018 The present invention relates to an information processing technique using a computer and especially to technique for calculating an evaluation value regarding an effect of a particular drug on a phenotype of a cancer-cell through a computer simulation using information regarding the cancer-cell and the drug.
Last Updated: 7/Oct/2018 The present invention relates to a nucleic acid detection kit and a nucleic acid detection method, which use nanoparticles and, more specifically, to: a nucleic acid detection method comprising a step of amplifying and labeling nucleic acids, and then capturing the same by using nanoparticles and centrifuging the sam...
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